Brimonidine would be of value as first-line therapy in patients who have contraindications to beta-blockers. It has been no effects on cardiopulmonary function. Brimonidine has hypotensor effect similar with timolol but with a greater incidence of adverse local reactions. Stimulation of the alpha - 2 adrenergic autoreceptor by norepinephrine in the synaptic cleft, or by alpha - 2 adrenergic receptor agonists, such as. Brimonidine has neuroprotective effect, which is an important feature in the new contexts of glaucoma pathogenesis. It has a lower incidence of the ocular adverse effects because of greater alpha 2 selectivity. Guanabenz, guanfacine, clonidine, tizanidine, medetomidine, and dexmedetomidine are all -2 agonists that vary in their potency and affinities for the various. Brimonidine became the alpha 2-agonist of choice in glaucoma chronic treatment, acting by decreasing aqueous humor secretion and increasing uveoscleral outflow. 2-adrenergic receptors include 3 highly homologous subtypes: 2A, 2B, and 2C.These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha2 agonists additionally provide muscle. It is not recommended as long term therapy due to its high incidence of local adverse reactions and tachyphylaxis. The alpha2 agonist family of drugs is notable for its predictable and quick onset of effective sedation. They are used to treat pain, opioid, benzodiazepine and alcohol withdrawal, symptoms of cigarette craving, high blood pressure, attention-deficit/hyperactivity disorder and panic disorder. ![]() It is employed to prevent or blunt the acute intraocular pressure rise after ocular laser therapy. The a-2 adrenergic agonists are a class of drugs used to treat multiple, distinctively different, conditions. Apraclonidine decrease the aqueous humor secretion and episcleral venous pressure. It is also used to aid in the diagnosis of. ![]() Clonidine: An alpha-2 adrenergic agonist used to treat hypertension and severe cancer pain, among other conditions, and to treat withdrawal symptoms from various substances. The first available alpha 2-agonist, clonidine is of historical importance today. An alpha-2 adrenergic agonist used to treat glaucoma and ocular hypertension, as well as facial erythema in rosacea. The study represent an up-to-date of the role and place of alpha 2-adrenergic agonists in glaucoma treatment.
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